Notable people with Down syndrome include:
* Stephane Ginnsz, actor (Duo) First actor with Down syndrome in the lead part of a motion picture. Duo won both the Martin Scorsese and the Warner Bros. Pictures Film Awards, was an official entry at the 23rd Student Academy Awards, Finalist at the 1996 Chicago International Children's Film Festival, Winner of the 1996 Wasserman Award for best cinematography and nominated for a TASH Film Award. For more info, please visit the official Duo film site and Stephane's official site.
* Chris Burke, actor (Life Goes On) and autobiographer
* Andrea Friedman, actor (Life Goes On), guest appearances on many other shows
* Pascal Duquenne, actor (Le Huitième Jour aka The Eighth Day, Toto le héros aka Toto the Hero)
* Anne de Gaulle (1928-1948), daughter of Charles de Gaulle
* Miguel Tomasin, singer with Argentinian avant-rock band Reynols