In 832 AD, Caliph al-Ma'mūn founded the famous House of Wisdom. There the methods of Gondeshapur were emulated; indeed, the House of Wisdom was staffed with graduates of the older Academy of Gondeshapur. It is believed that the House of Wisdom was disbanded under Al-Mutawakkil, al-Ma'mūn's successor.
However, by that time the intellectual center of the Abbasid Caliphate had definitively shifted to Baghdad, as henceforth there are few references in contemporary literature to universities or hospitals at Gondeshapur. The significance of the center gradually declined. Al-Muqaddasi's Best Divisions for Knowledge of the Regions (c. 1000 AD) described Gondeshapur as falling into ruins.