Genomic Psychiatry Cohort (GPC): Genomic Parsing of Bipolar Disorder and Schizophrenia: Studies of Large Cohorts in the U.S.

Focus of Study:

This study involves research in genetics that could be used to develop genetic testing in the future. If you decide to participate in this study, you will be involved in genetic research, not genetic testing

Purpose:

The purpose of this research study to create a large repository (database) at the NIMH of data and specimens collected from individuals diagnosed with schizophrenia and bipolar disorder: (‘NIMH Repository’) and from control subjects without schizophrenia or a family history of schizophrenia. The information stored in the Repository will be used in future research studies investigating how genetic makeup relates to schizophrenia and bipolar disorder. The purpose of the repository is to conduct further research using the collected blood samples to find genes that increase the chance of developing schizophrenia and bipolar disorder or that affect the disease course.

Condition:

Schizophrenia and Bipolar Disorder

Intervention:

none

Study Type:

Genomic Parsing

Study Design:

Normal
0

false
false
false

/* Style Definitions */
table.MsoNormalTable
{mso-style-name:"Table Normal";
mso-tstyle-rowband-size:0;
mso-tstyle-colband-size:0;
mso-style-noshow:yes;
mso-style-parent:"";
mso-padding-alt:0in 5.4pt 0in 5.4pt;
mso-para-margin:0in;
mso-para-margin-bottom:.0001pt;
mso-pagination:widow-orphan;
font-size:10.0pt;
font-family:"Times New Roman";
mso-ansi-language:#0400;
mso-fareast-language:#0400;
mso-bidi-language:#0400;}

Participation in the study involves :

· completion of a diagnostic interview,

· completion of demographic and family history questionnaire,

· donation of a small sample of blood (about 3 tablespoons).

Enrollment:

Active now

Study Start Date:

In progress

Primary Completion Date:

2013

Ages of Eligibility:

18 years of age or older n Meet diagnostic criteria for

Gender:

Both

Inclusion Criteria:

Normal
0

false
false
false

MicrosoftInternetExplorer4

/* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

1. Existing Diagnosis of Schizophrenia/Schizoaffective/ Bipolar

2. Fluent in English (reading, speaking, oral comprehension)

3. Caucasians, Hispanics, and African Americans.

Exclusion Criteria:

Normal
0

false
false
false

MicrosoftInternetExplorer4

/* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

1 History of significant drug or alcohol dependence

2. Diagnosis of Organic mental disorders (i.e., epilepsy, cerebral tumors, AIDS, other CNS infections, significant head trauma, mental retardation, autism).

3. Another first-degree relative has already participated in this study as either a case or control

Contacts:

Normal
0

false
false
false

MicrosoftInternetExplorer4

/* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

Research Department of Psychiatry and Behavioral Neurosciences

310.423.6515 | 310.423.0888

www.cedars-sinai.edu/psychresearch

Locations:

Normal
0

false
false
false

MicrosoftInternetExplorer4

Normal
0

false
false
false

MicrosoftInternetExplorer4

xCedars Sinai Medical Center

8730 Alden Drive, Rm. E123 Los Angeles, CA 90048

edars Sinai Medical Center

Sponsors & Collaborators:

Normal
0

false
false
false

/* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

This research study is sponsored by the National Institute of Mental Health (NIMH). The study sponsor provides funding to cover costs related to the conduct of this research study.

Investigators:

Normal
0

false
false
false

MicrosoftInternetExplorer4

st2\:*{behavior:url(#ieooui) }st1\:*{behavior:url(#ieooui) }

MarkHymanRapaport, MD

Chairman Department of Psychiatry Cedars-Sinai Medical Center

The Polier Endowed Chair in Schizophrenia and Related Disorders

Vice-Chairman and Professor in Residence Department of Psychiatry and Biobehavioral Science

David Geffen School of Medicine University of California, Los Angeles

Normal
0

false
false
false

MicrosoftInternetExplorer4

st1\:*{behavior:url(#ieooui) }

/* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

Study ID Numbers:

IRB No: Pro00016699/ CR00004579